enrofloxacin soluble powder 10% use for animal
The main components of the product: enrofloxacin,
[Properties] This product is white or light yellow powder.
Pharmacological effects Pharmacodynamics: This product is a bactericide for animal-specific broad-spectrum antibacterial drugs. Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. have a good effect on Pseudomonas aeruginosa, Streptococcus weak, little effect on anaerobic bacteria. This product MIC for most strains are less than 1μg / ml. On the sensitive bacteria have significant antibacterial effect (PAE). The antibacterial mechanism of this class of drugs is the DNA gyrase acting on bacterial cells, interfering with bacterial DNA replication, transcription and repair of recombinant bacteria can not grow and die normally. Its role in a significant concentration-dependent plasma concentration greater than 8 times MIC can play the best therapeutic effect. This product is suitable for cattle, pigs, poultry, dogs, cats and aquatic animals sensitive bacteria and mycoplasma caused by the digestive system, respiratory system, urinary system and skin and soft tissue infectious diseases. Mainly used for mycoplasma disease, Pasteurella disease, colibacillosis, salmonellosis, streptococcal disease.
Pharmacokinetics: most monogastric animals can be well absorbed orally, 0.5 ~ 2 hours peak plasma concentration, gastric food can delay the rate of drug absorption, but does not affect the number of absorption. Oral bioavailability, chicken 62.2% to 84%, dogs, pigs, non-ruminant calves 80% to 100%, less than 10% of ruminants. Intramuscular absorption quickly and completely, bioavailability of pigs 91.9%, 82% of cows, 92% of camels. In animals widely distributed, well into the tissues, body fluids (including bone and prostate), out of the concentration of cerebrospinal fluid concentration of only 6% to 10%, almost all tissue drug concentrations were higher than plasma, in leukocytes Accumulation of up to 140 times the plasma concentration. The apparent volume of distribution in dogs was 2.8 L / kg, and the plasma protein binding rate was 27%. Liver metabolism is mainly taken off the 7 - piperazine ring ethyl generated ciprofloxacin, followed by oxidation and glucuronidation. Elimination mainly through the kidneys (tubular secretion and glomerular filtration) excretion, 15% to 50% of excretion from the urine in the prototype. Half-life in different species of animals and different routes of administration are quite different, such as intravenous half-life of 1.7 to 2.3 hours of cattle, horses 4.4 hours, pig 3.5 hours, 5.3 to 10.3 hours of chicken, dogs 2.4 hours; intramuscular half-life of cows 5.9 hours, 9.9 hours of horses, 4.6 hours of pigs; 6.9 hours of oral half-life pigs, dogs 3.7 ~ 5.8 hours, chicken 9.1 ~ 14.2 hours.
Indications for chicken, pig Escherichia coli, white diarrhea, pasteurellosis and septic mycoplasma and so on.
[Matters needing attention] 1, Laying hens disabled. 2, This product does not apply to dogs before 8 weeks of age. 3, there is potential excitement on the central nervous system, induction of seizures, dogs suffering from epilepsy. 4, carnivores and renal dysfunction caution livestock, can be occasionally crystalline urine. 5, the drug-resistant strains into an increasing trend, should not be sub-therapeutic doses of long-term use.
[Usage and dosage] Enrofloxacin dollars. Mixed drink: every 1L of water, chicken 50 ~ 75mg, once every 3 to 5 days.
Adverse reactions This product is less toxic, clinical safe use.
[Hugh medicine] chicken on the 8th.
[Specification] 100g: 10g
[Packing] 25kg / bag
[Storage] shading, sealed, stored in a dry place.
[Validity] two years
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and secondary bacterial infections subsequent to viral conditions (e.g. viral pneumonia) where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
Diseases of the respiratory and alimentary tract of bacterial or mycoplasmal origin (e.g. pasteurellosis, actinobacillosis, mycoplasmosis, coli-bacillosis, coli-septicaemia and salmonellosis) and mulifactorial diseases such as atrophic rhinitis and enzootic pneumonia, where clinical experience, supported where possible by sensitivity testing of the causal organism, indicates enrofloxacin as the drug of choice.
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