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99% Purity Peptide Epithalon epitalon powder CAS 307297-39-8 accept Trade assurance 99% Purity Peptide Epithalon epitalon powder CAS 307297-39-8 accept Trade assurance 99% Purity Peptide Epithalon epitalon powder CAS 307297-39-8 accept Trade assurance

99% Purity Peptide Epithalon epitalon powder CAS 307297-39-8 accept Trade assurance

Introduction Product Name: Epitalon...
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Product Description

Introduction

Product Name: Epitalon
Synonyms: Epitalon;Epithalon;Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-;L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine;9: PN: WO02090380 PAGE: 55 claimed protein
CAS: 307297-39-8
MF: C14H22N4O9
MW: 390
Product Categories:

Amino Acid Derivatives;Peptide

Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity. The sequence of amino acids in the peptide is Alanine-Glutamate-Asparagine-Glycine. Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity. A summary of the studies and research on telomerase is provided below.

An endocrine gland-pineal gland of an animal secreting a peptide called "Epithalamin", which can be synthesized by artificially synthesizing the tetrapeptide (Ala-Glu-Asp-Gly) called "Epithalon" The It has been reported that Epithalon has a certain tumor inhibitory effect in animals. The purpose of this study is to study the effect of Epithalon on the growth of HepG2 cells, the telomere length and the telomerase activity of HepG2 cells. At the same time, the effects of Epithalon on telomere and telomerase were studied by comparing the changes of telomere length and telomerase activity with Epithalon on human fetal hepatocyte L-02, and to explore its possible role mechanism.

Function

Telomerase is a specific RNA (ribonucleic acid)-dependent polymerase that elongates and maintains the length of telomeres by adding tandem repeats on the chromosomal 3' end. The enzyme is composed of two parts: an RNA component which supplies the telomere template for elongation, and the catalytic subunit which possesses reverse transcriptase activity. These two parts work in tandem to avert telomere attrition especially in somatic cells. In vitro experiments have shown that telomere elongation promotes indefinite cellular proliferation and that suppression of telomerase activity promotes apoptosis of neoplastic cells. However, these studies have also shown that maintenance of telomere length within a range of 15-20 kilobase pairs does prevent tumorigenesis. All the research and studies done concerning telomerase do show that telomerase activity is limited to cell division through its action of stabilizing the telomere length.

Telomeres are located at either ends of a chromosome, and they do protect the adjacent gene sequence from shortening due to repeated replication cycles. Elongation of telomeres enables senescent cells to stabilize their telomeric length. However, excess elongation would enable such cells to exceed their Hayflick limit via evasion of apoptosis or the post-mitotic phase; and therefore, such cells have the potential of becoming immortal and this predisposes them to neoplastic transformation.

Human telomeres are made up of tandem repeats of the nucleotide sequence TTAGGG that form a T loop structure when associated with telomere-binding proteins. The T loop structure ensures the integrity of the telomeres by protecting them from constitutive degradation. These tandem repeats do shorten as a consequence of repeated chromosomal replication cycles. Such shortening is due to the inability of DNA polymerase to repeatedly replicate the nucleotides located in the T loop region. This leads to senescence or growth arrest, and a critically shortened telomere does induce a p53-mediated DNA checkpoint reaction. Some cells do evade senescence if they have nonfunctional p53 and/or pRb, but cell death still occurs due to either lethal DNA rearrangements or chromosomal fusion. Thus, evasion of telomere-mediated senescence is the main way that cells use to avert premature senescence and apoptosis. This occurs only when telomerase activity is up-regulated. Telomerase elongation leads to stabilization of the genotype as the rate of gene mutation is maintained within normal limits. However, an increase in the rate of apoptosis leads to a proportionate increase in cellular regeneration rate, and this causes an increase in the number of sporadic gene mutations that occur thus predisposing the person to pro-neoplastic mutations.

Current studies show that telomere shortening is associated with chronic diseases such as pulmonary fibrosis, coronary artery disease, diabetes mellitus and Alzheimer’s disease, though their findings are still considered inconclusive. Based on the findings of these studies, it can be theorized that Epithalon could prevent the development of these diseases.

Specification

Packaging Details:

25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside

Delivery Detail: within 3 days when get the payment

Shipping :

We have Professional shipping agent, based on customers ' demand for transport

By express :FEDEX,DHL,EMS ,UPS,TNT ect.

By SEA and By AIR

Xi'an sgonek biological Technology Co., Ltd., was established in July 2013. It is a professional animal and plant extracts modern and advanced enterprise object, pharmaceutical intermediates, and natural active ingredients. In the development, production and marketing, is very powerful.

Headquartered in Xi'an. It has a research and development center and the Analysis and Testing Center, with strong comprehensive national strength. The company has 200 acres of experimental field of plant cultivation, extraction, distillation, rectification, chromatography, three specialized production lines, as well as 10,000 square meters of GMP standard workshop. A variety of production equipment more than 200 sets of experiments. US company to introduce the company WATERS LC-MS chromatograph and a 8453 UV-Vis spectrophotometer and Switzerland TLC scanner (HPTLC) and other advanced detection equipment to ensure the quality of our products are oriented to international standards. Advanced equipment and professional and technical personnel, we are standing in front of the industry foundation, we thought to provide quality products and services to target customers around the word .

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